Past Trainees

Recipient of an Individual NRSA Predoctoral Fellowship (2018 – 2020)
PhD Awarded 2020: “Post-lysosomal cholesterol trafficking”

Present Position: Postdoctoral Fellow, Carnegie Institution for Science
Department of Embryology

Publications:

Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG. High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Hum Mol Genet. 2018 Jun 15;27(12):2101-2112.

Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. J Lipid Res. 2019 Mar;60(3):707-716.

Feltes M, Gale SE, Moores S, Ory DS, Schaffer JE. Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment. J Lipid Res. 2020 Mar;61(3):403-412.

Present Position: PhD Candidate in Biomedical Engineering (anticipated 5/2021)

Publications:

Mangold KE, Brumback BD, Angsutararux P, Voelker TL, Zhu W, Kang PW, Moreno JD, Silva JR. Mechanisms and models of cardiac sodium channel inactivation. Channels (Austin). 2017 Nov 2;11(6):517-533.

Moreno JD, Zhu W, Mangold K, Chung W, Silva JR. A Molecularly Detailed Na _V 1.5 Model Reveals a New Class I Antiarrhythmic Target. JACC Basic Transl Sci. 2019 Oct 28;4(6):736-751.

Recipient of an Individual NRSA Predoctoral Fellowship (2019 – 2021)

Present Position: MD/PhD Candidate (anticipated May 2022)

Publications:

Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE. Nuclear export factor 3 regulates localization of small nucleolar RNAs.  J Biol Chem. 2017 Dec 8;292(49):20228-20239.

Sletten AC, Peterson LR, Schaffer JE. Manifestations and mechanisms of myocardial lipotoxicity in obesity. J Intern Med. 2018 Nov;284(5):478-491.

Recipient of an Individual NRSA Predoctoral Fellowship (2020 – 2022)

Present Position: MD/PhD Candidate (anticipated May 2024)

Publications:

Hou P, Kang PW, Kongmeneck AD, Yang ND, Liu Y, Shi J, Xu X, White KM, Zaydman MA, Kasimova MA, Seebohm G, Zhong L, Zou X, Tarek M, Cui J. Two-stage electro-mechanical coupling of a K _V channel in voltage-dependent activation. Nat Commun. 2020 Feb 3;11(1):676.

Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR. Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. Elife. 2020 Feb 25;9:e53901

Zhang G, Gibson RA, McDonald M, Liang P, Kang PW, Shi J, Yang H, Cui J, Mikati MA. A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy. Mov Disord. 2020 Oct;35(10):1868-1873.

Publications:

Thompson MD, Derse A, Ferey J, Reid M, Xie Y, Christ M, Chatterjee D, Nguyen C, Harasymowicz N, Guilak F, Moley KH, Davidson NO. Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease. Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E674-E686.

Ferey JLA, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH. A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1202-H1210.

Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2020 Apr;158(5):1402-1416.e2.

Publications:

Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 Sep;597(17):4533-4564.

Kernik DC, Yang PC, Kurokawa J, Wu JC, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants. PLoS Comput Biol. 2020 Aug 14;16(8):e1008109.

Present Position: Medical Science Liaison, Myriad Neuroscience

Publications:

Cooper MA, Menta BW, Perez-Sanchez C, Jack MM, Khan ZW, Ryals JM, Winter M, Wright DE.A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice. Exp Neurol. 2018 Aug; 306: 149–157.

Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE. Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol. 2018 Sep;103(9):1206-1212.

Present Position: Postdoctoral Research Fellow, Washington University

Publications:

Bajpai G, Bredemeyer A, Li W, Zaitsev K, Koenig AL, Lokshina I, Mohan J, Ivey B, Hsiao HM, Weinheimer C, Kovacs A, Epelman S, Artyomov M, Kreisel D, Lavine KJ. Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury. Circ Res. 2019 Jan 18;124(2):263-278.

Wang Z, Koenig AL, Lavine KJ, Apte RS. Macrophage plasticity and function in the eye and heart. Trends Immunol. 2019 Sep;40(9):825-841.

Chestnut B, Casie Chetty S, Koenig AL, Sumanas S. Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nat Commun. 2020 Jun 3;11(1):2796.

Recipient of a KL2 Career Development Award in Clinical and Translational Research (2020 – 2021)

Present Position: Senior Scientist, SentiAR, Inc.

Publications:

Andrews C, Cupps BP, Pasque MK, Rudy Y. Electromechanics of the normal human heart In situ. Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007484.

Avari Silva JN, Southworth MK, Blume WM, Andrews C, Van Hare GF, Dalal AS, Miller N, Sodhi SS, Silva JR. First-in-human use of a mixed reality display during cardiac ablation procedures. JACC Clin Electrophysiol. 2020 Aug;6(8):1023-1025.